In: publications

In Vitro Liver Toxicity Testing of Chemicals: A Pragmatic Approach

11/05/2021

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The liver is among the most frequently targeted organs by noxious chemicals of diverse nature. Liver toxicity testing using laboratory animals not only raises serious ethical questions, but is also rather poorly predictive of human safety towards chemicals.

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Mechanisms Underlying Connexin Hemichannel Activation in Disease

30/04/2021

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Gap junctions and connexin hemichannels mediate intercellular and extracellular communication, respectively. While gap junctions are seen as the “good guys” by controlling homeostasis, connexin hemichannels are considered as the “bad guys”, as their activation is associated with the onset and dissemination of disease.

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Canonical and Non-Canonical Roles of Connexin43 in Cardioprotection

30/04/2021

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Since the mid-20th century, ischemic heart disease has been the world’s leading cause of death. Developing effective clinical cardioprotection strategies would make a significant impact in improving both quality of life and longevity in the worldwide population.

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